6ème congrès de la Société Française d'Angiogenèse
Collège de France, Paris
24-25 Septembre 2015



09h00-09h10 Welcome and Introduction
The Organizing Committee

09.15-10.45 Session 1: Vascular Network and Morphogenesis
Chairpersons: Jean-Jacques FEIGE - Stéphane GERMAIN
09.15-09.45 Invited speaker: K. ALITALO (Institute of Biomedicine, Helsinki, Finland)
VEGFs orchestrate networks and tissue functions
09.45-10.15 Invited speaker: R. ADAMS (Max Planck Institute, Munster, Germany)
New leaves on the vascular tree: organ-specifi c angiogenesis
10.15-10.30 L. SAUTEUR (Biozentrum, University of Basel, Switzerland)
VE-cadherin promotes dynamic cell shape changes during angiogenic sprouting
by cortical actin anchorage and actin polymerization
10.30-10.45 V. GEBALA (Cancer Research UK London, United Kingdom)
Blood fl ow drives lumen formation by inverse membrane blebbing during sprouting

10.45-11.15 Coffee Break

11.15-12.45 Session 2: Therapeutics: anti-angiogenesis in ophthalmology
Chairpersons: Olivier CUVILLIER - Fabrice SONCIN
11.15-11.45 S. BAILLIF (Hôpital Saint Roch, Nice, France)
Angiogenesis in ophthalmology
11.45-12.15 C. DOT (HIA Desgenettes, Lyon, France)
Mechanisms and specifi cities of anti-VEGFs in the eye
12.15-12.45 S. TICK (CHNO des XVXX, Paris, France)
Clinical applications

12.45-14.15 Lunch & Poster Session

14.15-15.45 Session 3: Therapeutics: anti-angiogenesis in cancer - Sponsored by ROCHE
Chairpersons: Marc POCARD - Gilles PAGES
14.15-14.45 Invited speaker: H. AUGUSTIN (German Cancer Research center, Heidelberg, Germany)
Targeting Angiopoietin/Tie signaling during tumor angiogenesis: Where do we stand?
14.45-15.15 Invited speaker: C. BORG (Institut Régional de Cancérologie de Franche Compté, CHU Besançon)
Anti-angiogenesis in oncology
15.15-15.30 T. MATHIVET (Vascular Patterning Laboratory, Leuven, Belgium)
Unraveling mechanisms in vascular patterning during tumor angiogenesis using
Multi-Photon in Vivo imaging in mouse glioma
15.30-15.45 H. CASTEL (Inserm U982, Mont-Saint-Aignan, France)
The vasoactive peptide urotensin II : a new chemokine exhibiting migration/adhesion
mesenchymal and angiogenic properties during glioma development
15.45-16.00 SPONSORED Session by NANOSTRING
R. VAN EIJSDEN, PhD. Nanostring Technologies (Netherlands) - Multiplexed Cancer
Progression Analysis: Using the nCounter® PanCancer Progression Panel

16.00-17.15 Coffee break & Poster Session

17.15-18.45 Session 4: Signaling and trafficking in angiogenesis
Chairpersons: Catherine MONNOT - Cécile DUPLAA
17.15-17.45 Invited speaker: L. CLAESSON-WELSH (Uppsala University, Sweden)
VEGF signaling regulating the endothelial barrier
17.45-18.15 Invited speaker: G. LOIRAND (Institut du Thorax, Nantes, France)
Functions and regulations of Rho proteins in endothelial cells
18.15-18.30 A. ROSSI (Max Planck Institute, Bad Nauheim, Germany)
VEGFR2-independent VEGFA signaling in early zebrafi sh embryos
18.30-18.45 C. PAQUES (GIGA-Research center, Molecular Angiogenesis Laboratory, Liège, Belgium)
Growth factors-induced angiogenesis requires the uPAR on the endothelial cells

Gala Dinner

09.00-10.30 Session 5: Regeneration and Vascular Functions
Chairpersons: Jean-Sébastien SILVESTRE - Ebba BRAKENHIELM
09.00-09.30 Invited speaker: S. RAFII (Cornell University, New-York, USA)
09.30-10.00 Invited speaker: S. OFFERMANNS (Bad Nauheim, Germany)
Endothelial GPCR signaling in angiogenesis and vascular homeostasis
10.00-10.15 O. HENRI (Inserm U1096, Rouen, France)
Therapeutic lymphangiogenesis in chronic heart failure
10.15-10.30 K.-Y. HOWANGYIN (INSERM UMRS 970, Cardiovascular Research Center, Paris, France)
Efferocytosis controls myeloid cell-derived vascular endothelial growth factor release
and cardiac remodeling after myocardial infarction

10.30-11.00 Coffee break

11.00-12.00 Session 6: Vascular Barrier & Signaling
Chairpersons: Julie GAVARD - Daniele MATHIEU
11.00-11.30 Invited speaker: E. DEJANA (University of Milan, Italy)
Transcriptional regulation of vascular development in health and disease
11.30-12.00 Invited speaker: D. VESTWEBER (Max Planck Institute, Munster, Germany)
Mechanisms that regulate endothelial junctions
12.15-12.30 G. BOULDAY (INSERM, UMR-1161,Paris, France)
Integrating transcriptome and interactome data pinpoints a vWF pathway deregulation
in Cerebral Cavernous Malformations
12.30-12.45 L. TREPS (INSERM U1016, Institut Cochin, Paris, France)
Extracellular vesicle-transported Semaphorin3A promotes vascular permeability in

12.45-14.00 Lunch

13.30-14.00 SFA General Assembly

14.00-15.30 Session 7: Molecular Mechanisms of Angiogenesis
Chairpersons: Thierry COUFFINHAL - Virginie MATTOT
14.00-14.30 Invited speaker: H. GERHARDT (London Research Institute, UK)
Mechanisms in vascular patterning – a tale of fate and forces
14.30-15.00 Invited speaker: A. EICHMANN (Yale University, USA)
15.00-15.15 F. TATIN (I2MC-INSERM U1048, Toulouse, France)
Fat4/Dachsous1 signalling orchestrates collective cell polarization
and migration during lymphatic valve morphogenesis
15.15-15.30 C. UMANA-DIAZ (INSERM U1050, College de France, Paris, France)
LOXL2 regulates vascular morphogenesis through collagen type IV assembly in the
extracellular matrix
15.30-15.45 S. GAUVRIT (Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany)
The transcription factor Hhex is necessary for venous sprouting and lymphatic
development in zebrafish

15.45-16.00 Coffee break

16.00-17.30 Session 8: Metabolism in the Vascular System
Chairpersons: Barbara GARMY-SUSINI - Andreas BIKFALVI
16.00-16.30 Invited speaker: P. CARMELIET (Vesalius Research Center, Leuven, Belgium)
Angiogenesis revisited: role and (therapeutic) implications of endothelial metabolism
16.30-17.00 Invited speaker: P. MADEDDU (University of Bristol, UK )
The impact of diabetes on angiogenesis and vasculogenesis
17.00-17.15 S. HERKENNE (Department of Biology, University of Padova, Italy)
The mitochondrial shaping protein Optic Atrophy 1 (OPA1) controls angiogenesis
17.15-17.30 C. ERPICUM (I2MC-INSERM U1048, Toulouse, France)
Lymphatic system drains peripheral adipose tissue to promote cachexia

17.30-17.45 Closing Ceremony
Best poster and best oral presentation Awards

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